A shared understanding of key priorities and the path forward is critical to improving reproductive, maternal, newborn, and child health (RMNCH) in humanitarian emergencies. Stakeholders, including local governments, multilateral, United Nations (UN) agencies, and non-governmental organization (NGO) partners, must plan and implement coherent programs to reduce disease burden while working with available financial resources. However, tools to support evidence-based decision making in the challenging context of humanitarian crises are lacking; the paucity of research conducted in a complex humanitarian setting poses additional constraints [1]. The Humanitarian Lives Saved Tool approach (H-LiST) responds to this need, drawing upon humanitarian health, evaluation, costing and modeling principles and evidence about effectiveness of RMNCH interventions from the existing Lives Saved Tool (LiST) model. Here, we present the conceptual framework (Figure 1), experiences implementing with in-country partners, and strengths and limitations of the current H-LiST approach. We then discuss gaps and next steps for refining and improving this accessible technical resource.