We plan to inovate the Digital Twin of the Disaster Healthcare System. As a decision tool for disaster healthcare, the Digital Twin will enable cost/resourcing analysis, disaster response planning, workforce projections and training, and system readiness (preparedness) assessment. It will also force the implementation of objective performance metrics. Recognizing the evolution of Disaster Healthcare as a complex socio-technological system, we apply Systems Thinking via System Dynamics Analysis (SDA) to create the analytic framework of Disaster Healthcare. Our proof-of-concept project focuses on Disaster Nursing as a collaboration between JHU Divisions – the Applied Physics Lab (JHU-APL), the School of Nursing (JHU-SON), and the Bloomberg School of Public Health (JHU-BSPH).