Dureab and colleagues concur with our call for urgent measures to enhance cholera preparedness and response in Yemen to stop the outbreak that has persisted for more than 2 years. However, they challenge our finding that the large second epidemic wave was associated with the start of the rainy season from April to May, 2017. They suggest that rainfall is unlikely to be a major risk factor for cholera transmission in Yemen because cholera and rainfall are spatially and temporally variable within the country, and because our analyses used modelled and not measured estimates of precipitation.