This collaboration between Johns Hopkins' Centre for Humanitarian Health and the Eastern Mediterranean Regional Office of WHO aims to strengthen the operationalization of a regional monitoring framework for health emergencies in humanitarian and fragile settings. Key steps include: i) assess monitoring capacity and identify current constraints; ii) develop and finalize the regional operational monitoring framework (including definition of key performance indicators and development of an assessment checklist); iii) operationalize the monitoring framework in two countries; iv) learn and share lessons that are relevant for other countries and regions of WHO.